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Lactulose

Lactulose

Lactulose, also known as lactulose or isomerized lactose, is produced by isomerization of lactose. It is a disaccharide in which galactose and fructose are combined with a β-1.4 glycosidic bond.


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Physiological Function of Lactulose As a Prebiotic

  • Not absorbed, not digested

  • Promote the proliferation of bifidobacteria

  • Improve intestinal flora

    Changes of Intestinal Microflora by Intake 4g Lactulose

Changes of Intestinal Microflora by Intake 4g Lactulose


 Bifidobacterium                Bacteroides             Eubacterium           Others


  • Stool water content, defecation frequency

    physiological-function-of-lactulose-as-a-prebiotic.jpg


  • Improve the intestinal environment

    physiological-function-of-saigao-lactulose-as-a-prebiotic.jpg


  • Fecal characteristics and microbiome

physiological-function-of-saigao-lactulose.jpg


Changes in Stool Characteristics and pH of Infants As Study Subjects

changes-in-stool-characteristics-and-ph-of-infants-as-study-subjects.jpg


Three formula powder and breast milk

Infants in the formula group containing isomerized lactose had higher rates of bifidobacteria and lower pH in their stools.

  • Fecal Characteristics and Gut Microbiota

lactulose-fecal-characteristics-and-gut-microbiota.jpg


  • Combinatorial effects of oligosaccharides

combinatorial-effects-of-oligosaccharides-sugar.jpg



JOURNAL OF JAPANESE SOCIETY OF CLINICAL NUTRITION 21(3,4):27-32 (2000)

The molecular formula of lactulose is as follows:


molecular-formula-of-lactulose.jpg

Formation of lactulose:

lactulose-formation.jpg


Advantages of Lactulose As a Food Raw Material

1. At present, lactulose has been used in New Zealand, Australia, Germany, Russia, Ukraine, South Korea, Vietnam, Japan and other countries in the fields of medicine, infant formula powder, dietary supplements, lactic acid bacteria beverages, yogurt and other fields.


2. Disaccharide structure, small molecular weight, low dosage


lactulose-advantages.jpg


3. Easy to detect


lactulose-advantages1.jpg

4. High product stability



lactulose-advantages2.jpg


5. Thermal stability of lactulose


lactulose-advantages3.jpg

The solution concentration is 10%

Heat treatment: 130 degrees for 10 minutes.


6. Stability of lactulose in artificial gastric acid.


lactulose-advantages4.jpg

7. The only oligosaccharide that can be used across borders in food and medicine


lactulose-advantages5.jpg


Other effects of lactulose

  • Promotes absorption of minerals calcium and magnesium

  • Prevent osteoporosis

  • Reduce body fat

  • Isomerized lactose improves blood glucose values on oral glucose tests in patients with non-insulin-dependent diabetes mellitus (type II)

  • Product containing dietary fiber and isomerized lactose reduces blood sugar and insulin levels in obese patients

  • Reduce cholesterol



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